There are many different antioxidant serums on the market, and it can be challenging to know which one is right for you; that’s why we’ve put together a list of the 10 best antioxidant serums based on safety, efficacy, and customer reviews.
Antioxidants are essential for overall health but are especially crucial for maintaining healthy, youthful skin. Antioxidants help to protect skin cells from damage caused by free radicals, which can lead to fine lines, wrinkles, and other signs of aging.
Whether you’re looking for an antioxidant serum to prevent future damage or one to help reverse existing damage, you’re sure to find the perfect product on our list.
Table of Contents
What Are Antioxidants?

Antioxidants are substances that can scavenge and neutralize free radicals in the body. Antioxidants protect cells against free radical damage and can also help to prevent the signs of aging.
Vitamins C and E, beta-carotene, and flavonoids are all forms of antioxidants, and fruits and vegetables include them. You can also take them as a supplement form.
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Benefits Of Using Antioxidant Serums
There are many benefits to using antioxidant serums, including reduced fine lines and wrinkles, improved skin texture, and reduced inflammation. Antioxidant serums can also help to protect skin from free radical damage caused by environmental factors such as pollution and ultraviolet (UV) radiation.
The 10 Best Antioxidant Serums
- SkinMedica C E Ferulic
- Dr. Dennis Gross B³Adaptive SuperFoods™ Stress Rescue Super Serum
- Murad Environmental Shield Rapid Age Spot and Pigment Lightening Serum
- SkinMedica TNS Recovery Complex
- Obagi Professional-C Serum 15%
- NEOCUTIS Bio Serum Firm Hydrating and AntiAging Serum 30mL
- ISDIN Flavo-C Ultraglican serum
- La Roche-Posay Redermic [C] Vitamin C Concentrate
- TruSkin Vitamin C Serum
- Paula’s Choice SKIN RECOVERY Super Antioxidant Serum
SkinMedica C E Ferulic Serum
[amazon box=”B00LLJIIO4″ template=”horizontal”]SkinMedica C E Ferulic Serum contains vitamins C and E in a formulation that slowly delivers high levels of vitamins C and E to the skin throughout the day to provide antioxidant protection. The base is applied evenly and smoothly. It contains the vitamin c and e that the skin needs to be healthy and radiant. Wash your hands before touching your eyes.
Apply each morning after cleansing, toning, and applying TNS Recovery Complex(R) and before applying moisturizer.
Apply to your entire face, neck, and chest if desired.
Apply a single pump daily onto the back of your hand and gently apply it to the skin.
Dr. Dennis Gross B³Adaptive SuperFoods™ Stress Rescue Super Serum
[amazon box=”B084C1PXFG” template=”horizontal”]Introducing Dr. Dennis Gross B³Adaptive SuperFoods™ Stress Rescue Super Serum, a powerful anti-stress serum that helps correct and prevents signs of stress such as worry lines, dullness, stress-induced flareups, and compromised skin.
Formulated with scientifically engineered microcapsules of superfoods, adaptogens, and niacinamide (B3), this unique serum boosts the absorption of vital nutrients to help recreate a beaming, youthful appearance.
Cruelty-free and vegan, this paraben-free formula is ideal for those looking to stress-proof their skin.
Niacinamide (B3), superfoods, and adaptogens generate a silky-smooth, hypoallergenic, and non-comedogenic anti-stress serum that addresses the 5 signs of stress-induced aging. Scientifically engineered microcapsules of powerful ingredients enhance the absorption of vital nutrients to correct and prevent signs of stress, such as worry lines, dullness, flares, and compromised skin.
Massage the capsules into clean, dry skin to trigger microcapsule dispersion for AM and PM. To achieve the best results, follow Dr. Dennis Gross Skincare’s choice of the moisturizing product after the Alpha Beta Daily Peel.
Stress can significantly damage your skin by triggering a stress response that can disrupt the microbiome and decrease collagen production. Stress-proof your skin with our cold-preserved B3Adaptive SuperFoods Complex. Maitake mushroom, maca root, cacao, and goji berry are powerful ingredients that help skin quickly recover from stress, smoothing worry lines, correcting flareups, reducing redness, and strengthening the skin barrier.
Murad Environmental Shield Rapid Age Spot And Pigment Lightening Serum
[amazon box=”B0785FST6D” template=”horizontal”]This serum helps even skin tone, targets signs of ageing, and increases skin’s radiance over time without hydroquinone. In just one week, this clinically-tested correcting face serum can dramatically reduce the appearance of dark spots, age spots, and hyperpigmentation. Works best on all skin types.
This serum increases cell turnover to visibly reduce dark spots, while focusing on key signs of aging and rejuvenating skin’s natural tone.
Vitamin C is a potent antioxidant that supports healthier-looking skin and can neutralize oxidants to help prevent visible skin damage.
SkinMedica TNS Recovery Complex
[amazon box=”B07SCJ445R” template=”horizontal”]TNS Advanced+ Serum is clinically proven to smooth wrinkles, fine lines, sagging skin, and restructure skin. Users reported looking six years younger in just a few weeks. It has been shown to smooth the look of wrinkles and fine lines, treat sagging and rejuvenate skin.
Dispense single pump onto the back of hand, blend together & apply to face morning & night. Avoid getting in eyes.
My wife uses the product twice daily on her face, neck, and upper chest. She estimates that she uses two pumps twice daily, so four pumps per day, so the 1 ounce bottle should last for about two months.
Obagi Professional-C Serum 15%
[amazon box=”B00F6XZVHS” template=”horizontal”]It is a highly concentrated serum containing antioxidant L-ascorbic acid that will work on most skin types and will help reduce the appearance of fine lines and wrinkles, while leaving your skin silky soft.
Skin changes are some of the most visible signs of aging, but with good skin care and smart lifestyle choices, you can help to reduce their appearance.
This Obagi Professional-C Serum 15% helps to reduce fine lines and wrinkles, while giving you Vitamin C’s powerful benefits in a rich, concentrated formula.
Do You Need To Keep It In Fridge After Opened?
After opening, this product does not require refrigeration, and I keep mine in my makeup bag in its original box. As with all cosmetics and skin care products, it will be best to keep it away from extreme heat, and with this product, from the light.
NEOCUTIS Bio Serum Firm Hydrating And AntiAging Serum 30mL
[amazon box=”B081KMCB8X” template=”horizontal”]This supercharged serum combines NEOCUTIS‘ powerhouse technologies with supporting ingredients for superior anti-aging results and is made with the highest concentration of Proprietary Peptides + Human Growth Factors available.
Nourishes and restores collagen, elastin, and hyaluronic acid for a more youthful appearance.
Is It Worth The Money?
It is a good product, but it’s expensive. I used Neocutis products for years and they certainly did make a difference in the appearance of my skin.
ISDIN Flavo-C Ultraglican Serum
[amazon box=”B0882B41Z5″ template=”horizontal”]Hyaluronic Booster is a lightweight serum in an ampoule that will help to rehydrate your skin and give it a glowing glow. It boosts the skin’s natural moisture levels, giving it instant, effective hydration for up to 72 hours.
Hyaluronic Booster ampoules can be used in your morning and evening skincare routines.
The ampoule should be inserted into the protective tube and broken open, then placed into the special applicator tip and the cap removed.
Massage ½ of the serum over face, neck, and neckline, avoiding the eye area.
La Roche-Posay Redermic [C] Vitamin C Concentrate
[amazon box=”B07PM79MSC” template=”horizontal”]A luxurious serum with a rich, creamy texture that leaves skin feeling softer and more hydrated. With 10% Pure Vitamin C, Salicylic Acid, and Neurosensine, this anti-aging facial serum is a little bit of heaven on the skin. Allergy-tested formula with fragrance that makes skin appear more radiant and visibly refined. With Pure 10% Vitamin C serum, skin’s radiance is boosted while wrinkles are reduced and skin texture refined.
The combination of vitamins and minerals is found in a blend of natural compounds, including vitamins A, C, E, and K, and vitamins K, C, E, and K. Apply 3-4 drops of this face serum daily to the face and neck, either alone or as an add-on to your moisturizer. Aim at avoiding contact with the eyes.
Anti-aging vitamin c face and neck serum leaves skin more radiant, softer, and hydrated from its rich serum texture. Pure Vitamin C can yellow upon contact with the air, but it is still effective.,, Skin-friendly formula that is perfect for sensitive skin.
TruSkin Vitamin C Serum
[amazon box=”B01M4MCUAF” template=”horizontal”]Bring brightness back to your skin with this refreshing, anti-aging face serum. Made with natural ingredients like Vitamin C, Botanical Hyaluronic Acid, and Jojoba Oil, this facial serum is designed to improve the appearance of dark spots, fine lines, and wrinkles. Our customers rave about how quickly they see results after using TruSkin Vitamin C Serum for Face.
Can I Use It In During The Day With Sunblock?
Absolutely, Vitamin C is well-known for helping to protect skin from the sun. Our customers who apply 3-5 drops of the Vitamin C Serum morning and night, followed by a moisturizer, report the best results.
Can I Use This In My Homemade Creams?
We recommend applying the serum first before cream to ensure that all the ingredients are fully absorbed, but there have been reports from customers who have blended it into their own creams and oils and found excellent results. If you decide to give it a try, please leave a review. It was a very cold day.
Paula’s Choice SKIN RECOVERY Super Antioxidant Serum with Retinol
[amazon box=”B00949EWFW” template=”horizontal”]This powerful serum contains retinol, which helps to visibly reduce the appearance of wrinkles and fine lines.The combination of hyaluronic acid and antioxidants in this serum help to restore a dewy, hydrated glow to the skin.
This serum has a silky-smooth texture that absorbs easily into the skin, leaving it feeling soft and smooth.This serum is gentle enough for sensitive skin, including skin prone to eczema.
Will This Help With My Dehydrated Skin?
It contains retinol, which is terrible for hydration. It was not really hydrating for me, but I never needed this feature in this product. I purchased HydrExtreme at Costco.
Will This Help Dry Flakey Skin Around The Eyes?
Yes, it is good for dry skin, and gentle enough to use around the eyes.
How To Use Antioxidant Serums
Some antioxidant serums can be applied once or twice a day, either in the morning or at night. You Can Apply a small amount of serum to clean, dry skin and massage it until it is fully absorbed. If you spend time outdoors, you can follow your usual skincare routine, including a moisturizer and sunscreen.

FAQ – Best Antioxidant Serums
Most antioxidant serums can be used once or twice daily, e9. Vitamin C serum with hyaluronic acid either in the morning or at night.
Results vary depending on the specific serum you use, but you may start to see results after 4-8 weeks of regular use.
Some antioxidant serums contain ingredients that may make your skin more sensitive to sunlight, so it is essential to use sunscreen when using these products. Talk to your dermatologist if you have concerns about sun sensitivity.
Conclusion – Best Antioxidant Serums To Rejuvenate Your Skin
The 10 best antioxidant serums can help rejuvenate your skin by reducing the appearance of wrinkles, fine lines, and age spots. Antioxidants work to protect the skin from damage caused by free radicals, which are unstable molecules that can cause cell damage. Free radicals are produced when the skin is exposed to sunlight, pollution, and other environmental toxins. By using an antioxidant serum, you can help to reduce the damage caused by free radicals.
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