There are many different antioxidant serums on the market, and it can be challenging to know which one is right for you; that’s why we’ve put together a list of the 10 best antioxidant serums based on safety, efficacy, and customer reviews.
Antioxidants are essential for overall health but are especially crucial for maintaining healthy, youthful skin. Antioxidants help to protect skin cells from damage caused by free radicals, which can lead to fine lines, wrinkles, and other signs of aging.
Whether you’re looking for an antioxidant serum to prevent future damage or one to help reverse existing damage, you’re sure to find the perfect product on our list.
What Are Antioxidants?

Antioxidants are substances that can scavenge and neutralize free radicals in the body. Antioxidants protect cells against free radical damage and can also help to prevent the signs of aging.
Vitamins C and E, beta-carotene, and flavonoids are all forms of antioxidants, and fruits and vegetables include them. You can also take them as a supplement form.
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Benefits Of Using Antioxidant Serums
There are many benefits to using antioxidant serums, including reduced fine lines and wrinkles, improved skin texture, and reduced inflammation. Antioxidant serums can also help to protect skin from free radical damage caused by environmental factors such as pollution and ultraviolet (UV) radiation.
The 10 Best Antioxidant Serums
- SkinMedica C E Ferulic
- Dr. Dennis Gross B³Adaptive SuperFoods™ Stress Rescue Super Serum
- Murad Environmental Shield Rapid Age Spot and Pigment Lightening Serum
- SkinMedica TNS Recovery Complex
- Obagi Professional-C Serum 15%
- NEOCUTIS Bio Serum Firm Hydrating and AntiAging Serum 30mL
- ISDIN Flavo-C Ultraglican serum
- La Roche-Posay Redermic [C] Vitamin C Concentrate
- TruSkin Vitamin C Serum
- Paula’s Choice SKIN RECOVERY Super Antioxidant Serum
SkinMedica C E Ferulic Serum
- Improve the appearance of skin tone and texture
- Enhanced skin brightness for a more youthful appearance
- Time-release system delivers vitamin c and e throughout the day
- TSA Friendly Skin Care
SkinMedica C E Ferulic Serum contains vitamins C and E in a formulation that slowly delivers high levels of vitamins C and E to the skin throughout the day to provide antioxidant protection. The base is applied evenly and smoothly. It contains the vitamin c and e that the skin needs to be healthy and radiant. Wash your hands before touching your eyes.
Apply each morning after cleansing, toning, and applying TNS Recovery Complex(R) and before applying moisturizer.
Apply to your entire face, neck, and chest if desired.
Apply a single pump daily onto the back of your hand and gently apply it to the skin.
Dr. Dennis Gross B³Adaptive SuperFoods™ Stress Rescue Super Serum
- WHAT IT IS: Scientifically engineered microcapsules of superfoods, adaptogens, and niacinamide (B3) in a powerful anti-stress serum for boosted absorption of vital nutrients. Helps correct and prevent visible signs of stress such as worry lines, dullness, stress-induced flareups, and compromised skin.
- WHAT'S IN IT FOR YOU: Stress wreaks havoc on skin by triggering a stress response that can disrupt your microbiome and inhibit collagen production. Recreate a beaming, youthful appearance with our new scientific advancement of microencapsulated superfoods, adaptogens, and niacinamide (B3).
- CRUELTY-FREE: Vegan, Paraben-Free, and Cruelty-Free Formula. Scientifically engineered microcapsules of powerful ingredients boost absorption of vital nutrients to help correct and prevent visible signs of stress such as worry lines, dullness, flareups, and compromised skin.
- STRESS-FREE SKIN: Stress wreaks havoc on skin by triggering a stress response that can disrupt your microbiome and inhibit collagen production. Stress-proof your skin with our unique cold-preserved B3Adaptive SuperFoods Complex.
- Dennis Gross, MD, is a board-certified dermatologist and dermatological surgeon who has been in practice for 25+ years. He is well-known for his expertise in skin health as well as his approach to creating and maintaining the most natural-looking skin utilizing state-of-the-art cosmetic treatments and dermatologic technology.
Introducing Dr. Dennis Gross B³Adaptive SuperFoods™ Stress Rescue Super Serum, a powerful anti-stress serum that helps correct and prevents signs of stress such as worry lines, dullness, stress-induced flareups, and compromised skin.
Formulated with scientifically engineered microcapsules of superfoods, adaptogens, and niacinamide (B3), this unique serum boosts the absorption of vital nutrients to help recreate a beaming, youthful appearance.
Cruelty-free and vegan, this paraben-free formula is ideal for those looking to stress-proof their skin.
Niacinamide (B3), superfoods, and adaptogens generate a silky-smooth, hypoallergenic, and non-comedogenic anti-stress serum that addresses the 5 signs of stress-induced aging. Scientifically engineered microcapsules of powerful ingredients enhance the absorption of vital nutrients to correct and prevent signs of stress, such as worry lines, dullness, flares, and compromised skin.
Massage the capsules into clean, dry skin to trigger microcapsule dispersion for AM and PM. To achieve the best results, follow Dr. Dennis Gross Skincare’s choice of the moisturizing product after the Alpha Beta Daily Peel.
Stress can significantly damage your skin by triggering a stress response that can disrupt the microbiome and decrease collagen production. Stress-proof your skin with our cold-preserved B3Adaptive SuperFoods Complex. Maitake mushroom, maca root, cacao, and goji berry are powerful ingredients that help skin quickly recover from stress, smoothing worry lines, correcting flareups, reducing redness, and strengthening the skin barrier.
Murad Environmental Shield Rapid Age Spot And Pigment Lightening Serum
- CLINICALLY PROVEN TO REPAIR YOUR SKIN: This powerful age spot formula from Murad is a clinically proven serum that reduces the appearance of dark spots, age spots and hyperpigmentation with a hydroquinone alternative.
- PROPRIETARY ANTI AGING FORMULA: With proprietary NHP-3 technology—a blend of 3 powerful ingredients Niacinamide, Hexylresorcinol and Plankton Extract—this spot corrector also evens skin tone and addresses key signs of aging, while reducing the appearance of fine lines and wrinkles and reinforces the skin's firmness.
- NUTRIENTS FOR YOUR SKIN: This anti aging serum contains Vitamin C, Oligopeptides and subtle light-reflecting pearls to enhance your skin’s radiance and help brighten tone instantly and over time, while enhancing cell turnover for the continuous renewal of your skin's surface.
- WHAT ELSE DO I NEED?: Rapid Age Spot Correcting Serum can be used in any Muard skincare regimen as part of Dr. Murad's inclusive health system of care. Pair with Essential-C Cleanser, Essential-C Day Moisture, and City Skin Overnight Detox Moisture for optimal results.
- IT'S NOT SKINCARE, IT'S MURAD: Murad is founded on the simple truth that living younger is a choice you can make every day. 25 years ago Dr. Howard Murad founded the first modern doctor brand of clinical skincare products, with a goal of making beautiful, healthy skin attainable for everyone. He has changed how the world sees skincare through his pioneering research and a Connected Beauty philosophy.
This serum helps even skin tone, targets signs of ageing, and increases skin’s radiance over time without hydroquinone. In just one week, this clinically-tested correcting face serum can dramatically reduce the appearance of dark spots, age spots, and hyperpigmentation. Works best on all skin types.
This serum increases cell turnover to visibly reduce dark spots, while focusing on key signs of aging and rejuvenating skin’s natural tone.
Vitamin C is a potent antioxidant that supports healthier-looking skin and can neutralize oxidants to help prevent visible skin damage.
SkinMedica TNS Recovery Complex
- Country Of Origin: United States
- Item Package Dimension: 3.0" L x 3.0" W x 7.75" H
- Item Package Weight: 0.25 lb
TNS Advanced+ Serum is clinically proven to smooth wrinkles, fine lines, sagging skin, and restructure skin. Users reported looking six years younger in just a few weeks. It has been shown to smooth the look of wrinkles and fine lines, treat sagging and rejuvenate skin.
Dispense single pump onto the back of hand, blend together & apply to face morning & night. Avoid getting in eyes.
My wife uses the product twice daily on her face, neck, and upper chest. She estimates that she uses two pumps twice daily, so four pumps per day, so the 1 ounce bottle should last for about two months.
Obagi Professional-C Serum 15%
- Visibly Youthful Skin - You'll love the way your skin looks after using this 15% Vitamin C Serum! It helps minimize the appearance of fine lines and wrinkles and is especially great for normal to oily skin. Plus, it brightens the area around your eyes to help your skin look younger as well.
- Brighten Up Your Skin!- Experience the true brightness of your skin with this hydrating serum . With its fast-acting formula, it will immediately penetrate the skin to enhance brightness & with regular use you’ll be glowing with joy at how great your skin looks. Great for normal to oily skin.
- Long-Lasting Hydration -Looking for a face skin care product that can provide lasting hydration? Look no further! Our Vitamin C Skin Care Serum is a brightening serum provides superior moisture retention, leaving your skin hydrated and refreshed for longer. Unlock the power of long-lasting hydration today!
- Skin Soothing Serum - Calm and soothe your skin with Obagi’s Vitamin-C Face Serum. This skin repair serum’s calming and moisturizing effects will help you look and feel relaxed and refreshed and its special combination of L-Ascorbic Acid & other medically formulated ingredients will help minimize the appearance of unwanted fine lines & wrinkles as well.
- Protect Your Skin - Our clinically formulated Vitamin C facial serum antiaging product has been designed to help retain moisture & protect your skin from environmental stressors. This face serum for women also provides nourishment and refreshes the skin so that you can have peace of mind knowing your skin is well protected from the elements
It is a highly concentrated serum containing antioxidant L-ascorbic acid that will work on most skin types and will help reduce the appearance of fine lines and wrinkles, while leaving your skin silky soft.
Skin changes are some of the most visible signs of aging, but with good skin care and smart lifestyle choices, you can help to reduce their appearance.
This Obagi Professional-C Serum 15% helps to reduce fine lines and wrinkles, while giving you Vitamin C’s powerful benefits in a rich, concentrated formula.
Do You Need To Keep It In Fridge After Opened?
After opening, this product does not require refrigeration, and I keep mine in my makeup bag in its original box. As with all cosmetics and skin care products, it will be best to keep it away from extreme heat, and with this product, from the light.
NEOCUTIS Bio Serum Firm Hydrating And AntiAging Serum 30mL
- Country Of Origin: United States
- Item Package Dimension: 1.6" L x 1.6" W x 4.8" H
- Item Package Weight: 0.25625 lb
This supercharged serum combines NEOCUTIS‘ powerhouse technologies with supporting ingredients for superior anti-aging results and is made with the highest concentration of Proprietary Peptides + Human Growth Factors available.
Nourishes and restores collagen, elastin, and hyaluronic acid for a more youthful appearance.
Is It Worth The Money?
It is a good product, but it’s expensive. I used Neocutis products for years and they certainly did make a difference in the appearance of my skin.
ISDIN Flavo-C Ultraglican Serum
- Intensive hydrating serum
- Hydrates: Boosts the skin’s natural moisture levels, providing quick, effective hydration lasting for up to 72 hours after application.
- Plumps: Reduces the appearance of fine lines and wrinkles, helping recharge dull, tired-looking skin and offering a plumping effect.
- Soothes: Intensely moisturizes and calms skin, while helping to reduce the feeling of dryness associated with dehydration.
- Usage: can be used in your morning and evening skincare routines
Hyaluronic Booster is a lightweight serum in an ampoule that will help to rehydrate your skin and give it a glowing glow. It boosts the skin’s natural moisture levels, giving it instant, effective hydration for up to 72 hours.
Hyaluronic Booster ampoules can be used in your morning and evening skincare routines.
The ampoule should be inserted into the protective tube and broken open, then placed into the special applicator tip and the cap removed.
Massage ½ of the serum over face, neck, and neckline, avoiding the eye area.
La Roche-Posay Redermic [C] Vitamin C Concentrate
- This anti-aging vitamin c face serum leaves skin more radiant, softer, and hydrated to help treat skin concerns like wrinkles, fine lines, lack of radiance, elasticity, and uneven skin tone.
- As a result, wrinkles look visibly reduced and skin texture and tone are more even and refined. This serum combines concentrated 10% pure vitamin c, salicylic acid and neurosensine for optimal effectiveness while also being suitable for sensitive skin.
- 10% pure vitamin c serum for face hydrates skin and visibly boosts radiance. Rich serum texture leaves skin feeling softer and more hydrated. Use alone or as an added boost to your favorite moisturizer.
- Key ingredients include pure vitamin c known for its anti-aging and antioxidant properties, salicylic acid known for its effective exfoliating properties to help clear and refine pores, and hyaluronic acid known for its hydrating and plumping properties.
- Pure vitamin c can react on contact with the air, causing it to turn yellow. But it’s still effective.
A luxurious serum with a rich, creamy texture that leaves skin feeling softer and more hydrated. With 10% Pure Vitamin C, Salicylic Acid, and Neurosensine, this anti-aging facial serum is a little bit of heaven on the skin. Allergy-tested formula with fragrance that makes skin appear more radiant and visibly refined. With Pure 10% Vitamin C serum, skin’s radiance is boosted while wrinkles are reduced and skin texture refined.
The combination of vitamins and minerals is found in a blend of natural compounds, including vitamins A, C, E, and K, and vitamins K, C, E, and K. Apply 3-4 drops of this face serum daily to the face and neck, either alone or as an add-on to your moisturizer. Aim at avoiding contact with the eyes.
Anti-aging vitamin c face and neck serum leaves skin more radiant, softer, and hydrated from its rich serum texture. Pure Vitamin C can yellow upon contact with the air, but it is still effective.,, Skin-friendly formula that is perfect for sensitive skin.
TruSkin Vitamin C Serum
- SKIN BRIGHTENING SERUM: Our most popular face & eye serum uses vitamin C to even skin tone, neutralize free radicals and boost collagen, thus improving radiance and reducing dark spots, fine lines and wrinkles
- PLANT-BASED, SKIN-FRIENDLY FORMULATIONS: Our anti aging serum is a purposefully balanced blend for skin nutrition, harnessing support from botanical hyaluronic acid, vitamin E, aloe vera, jojoba oil and MSM to help brighten, calm and protect skin
- PURE & POTENT SKIN CARE: Vegan and cruelty-free skin nourishment using antioxidants, nutrients and botanical actives to improve skin wellness, all in a fragrance free formula without parabens and other harmful chemicals you don’t want
- DIRECTIONS: TruSkin Vitamin C Serum for face with hyaluronic acid can be used morning and/or night. Apply 3-5 drops of serum to clean fingertips, palm or back of hand and use fingertips to gently smooth onto face and under eyes
- EXTENDED MANUFACTURER GUARANTEE: Love it or your money back! If for any reason you decide this product isn't a fit for your skin, we offer a 90-day money-back refund. The expiration date is printed on the barcode sticker attached to the packaging. For your safety, please ensure you purchase this product as sold by TruSkin Naturals and shipped from Amazon.
Bring brightness back to your skin with this refreshing, anti-aging face serum. Made with natural ingredients like Vitamin C, Botanical Hyaluronic Acid, and Jojoba Oil, this facial serum is designed to improve the appearance of dark spots, fine lines, and wrinkles. Our customers rave about how quickly they see results after using TruSkin Vitamin C Serum for Face.
Can I Use It In During The Day With Sunblock?
Absolutely, Vitamin C is well-known for helping to protect skin from the sun. Our customers who apply 3-5 drops of the Vitamin C Serum morning and night, followed by a moisturizer, report the best results.
Can I Use This In My Homemade Creams?
We recommend applying the serum first before cream to ensure that all the ingredients are fully absorbed, but there have been reports from customers who have blended it into their own creams and oils and found excellent results. If you decide to give it a try, please leave a review. It was a very cold day.
Paula’s Choice SKIN RECOVERY Super Antioxidant Serum with Retinol
- DEEP HYDRATION SERUM: This high-performance, silky-smooth serum contains a blend of beneficial ingredients for dry skin to reestablish a dewy, hydrated glow & improve the appearance of wrinkles. It has a luxuriously rich texture & absorbs easily into skin
- Paula's Choice SKIN RECOVERY Super Antioxidant Serum with Retinol is formulated to smooth and soften the skin while lessening the visible effects of aging on the face and neck. This serum is gentle enough for sensitive skin including skin prone to eczema.
- Use Paula's Choice SKIN RECOVERY hydrating, anti-aging serum twice daily as part of your morning & evening skin care, along with your favorite Paula's Choice cleanser, toner, exfoliator, serums, spot treatments & moisturizer with SPF for daytime wear.
- Paula's Choice products are made with YOUR SKIN in mind. Whatever your skincare concern, whether dryness, acne, fine lines, or sensitive skin; we've got a treatment line for you. The search for amazing skin care ends here. Finally, you found it.
- Paula's Choice Skincare makes products that work. No fragrance, no parabens, no fluff. Just effective, science-backed formulas that target any concern from wrinkles to breakouts.
This powerful serum contains retinol, which helps to visibly reduce the appearance of wrinkles and fine lines.The combination of hyaluronic acid and antioxidants in this serum help to restore a dewy, hydrated glow to the skin.
This serum has a silky-smooth texture that absorbs easily into the skin, leaving it feeling soft and smooth.This serum is gentle enough for sensitive skin, including skin prone to eczema.
Will This Help With My Dehydrated Skin?
It contains retinol, which is terrible for hydration. It was not really hydrating for me, but I never needed this feature in this product. I purchased HydrExtreme at Costco.
Will This Help Dry Flakey Skin Around The Eyes?
Yes, it is good for dry skin, and gentle enough to use around the eyes.
How To Use Antioxidant Serums
Some antioxidant serums can be applied once or twice a day, either in the morning or at night. You Can Apply a small amount of serum to clean, dry skin and massage it until it is fully absorbed. If you spend time outdoors, you can follow your usual skincare routine, including a moisturizer and sunscreen.

FAQ – Best Antioxidant Serums
Most antioxidant serums can be used once or twice daily, e9. Vitamin C serum with hyaluronic acid either in the morning or at night.
Results vary depending on the specific serum you use, but you may start to see results after 4-8 weeks of regular use.
Some antioxidant serums contain ingredients that may make your skin more sensitive to sunlight, so it is essential to use sunscreen when using these products. Talk to your dermatologist if you have concerns about sun sensitivity.
Conclusion – Best Antioxidant Serums To Rejuvenate Your Skin
The 10 best antioxidant serums can help rejuvenate your skin by reducing the appearance of wrinkles, fine lines, and age spots. Antioxidants work to protect the skin from damage caused by free radicals, which are unstable molecules that can cause cell damage. Free radicals are produced when the skin is exposed to sunlight, pollution, and other environmental toxins. By using an antioxidant serum, you can help to reduce the damage caused by free radicals.
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